Nkululeko Khumalo was born in 1980 in the Vaal Triangle. In 2003, Khumalo enrolled at the Vaal University of Technology, and thereafter completed a BTech degree. She taught art and design at the Sedibeng College in Vanderbijlpark and enrolled in a Masters degree in Fine Art under Heritage Studies. She was selected by Development Bank of Southern Africa to do an artists mentoring program, as well as a residency program at the Greatmore Studio. She worked on numerous exhibitions for the Department of Sports, Art, and Culture and Recreation, Bodutu Gallery, and various community projects.