Posted on July 26, 2022
One of several 58 studies included in the detailed study, 41 had been instance records, you to definitely try an incident series, 13 was retrospective cohort knowledge, a couple have been prospective cohort studies, and one try a mix-sectional cohort study. The feminine NF1 people that have breast cancer originated in 23 different countries, for the most of him or her via the usa off The usa (38%), United kingdom (31%), and you may Japan (12%). Qualities of these instances was explained when you look at the Desk 1.
Breast cancer stage at time of diagnosis was reported in 54 cases (27 cases of patients < 50 years of age and 27 cases of patients ?50 years of age)
Of the 286 cases identified, 181 reported the age of the patient. Mean age at breast cancer diagnosis was 49.3 years with a median age of 46 years and an interquartile range of 38.3 to 58.0 years. The majority of the patients were < 50 years of age with 53% < 50 years old, 28% between 35 and 44 years old and 15% < 35 years old. Age distribution of the incidence of breast cancer identified in these NF1 cases was evaluated based on their age at the time of diagnosis and revealed a peak age of diagnosis between the ages of 34 to 44 years. 2a).
Descriptive investigation from cancer of the breast times claimed. good Years distribution of your own occurrence away from cancer of the breast identified during the 181 NF1 customers compared to SEER database claimed breast cancer ages shipments regarding incident times. b Delivery away from breast cancer phase during the time of analysis off breast cancer identified for the 54 NF1 patients. c Many years shipments of your incidence off breast cancer demise known within the 76 NF1 customers than the SEER databases claimed breast disease ages shipping out of deaths
So it incidence of breast cancer cases try as compared to SEER database getting reported cancer of the breast decades shipments out-of experience instances, which displayed a peak ages of prognosis between your age of 55 to 64 years from the general population (Fig
The type of breast cancer was reported in 110 cases; invasive ductal carcinoma (IDC) was the most commonly reported breast cancer subtype (75.5%). The other 176 breast cancer cases were identified as breast carcinoma. When analyzing all the female NF1 patients with breast cancer, the majority presented with stage I or II disease http://www.datingranking.net/nl/yubo-overzicht/. However, when separated by age, women < 50 years of age presented with more advanced disease compared to those ?50 years of age (56% vs. 22% stage III-IV, respectively, p = 0.005; Fig. 2b).
Follow-up information was provided in 76 of the reported cases. Mean follow-up time was 44.7 months with a range of 1.9 to 204 months. Nearly half of the reported patients were dead at the time of last follow-up. Mean age at breast cancer death was 45.7 years with a median age of 48.5 years and an interquartile range of 41.3–59.7 years. The majority of the patients were < 50 years of age at time of breast cancer death with 64% < 50 years old, 38% between 35 and 44 years old and 10% < 35 years old. This incidence of breast cancer deaths was compared to the SEER database for reported breast cancer age distribution of deaths, demonstrating a peak age of death between the ages of 55 to 64 years in the general population (Fig. 2c). The relative survival of the female NF1 patients with breast cancer identified in this study was compared to the general population using the SEER database controlling for age and year at diagnosis for each patient (Fig. 3). The median survival for this entire NF1 breast cancer cohort was 5 years compared to the reported median breast cancer survival of over 20 years in the general population using the SEER database. When separated by age, the median survival of the female NF1 patients with breast cancer identified in this study was 5.58 years in those < 50 years of age and over 15 years in those ?50 years of age.