Posted on July 30, 2022
Information on effects of food on the pharmacokinetics of 48 compounds (66.7%) out of the 72 investigated oral antineoplastic drugs was obtained. There were 30 compounds for which dietary conditions were defined in the usages or the precautions described in the package inserts; 15 compounds required postprandial administration, and the other 15 compounds required fasting administration (Table 1). The medians (maximumimum, minimum) of the AUC ratios, Cmax ratios and Tmax ratios were 1.08 (8.96, 0.61), 0.94 (, 0.30) and 1.91 (3.92, 0.50), respectively. There was a positive correlation between ln (AUC ratio) and ln (Cmax ratio) (r 2 = 0.86) (Fig. 1).