Posted on April 29, 2022
I aligned to evaluate the fresh new connectivity between calcium and differing degree off colorectal carcinogenesis and you will if or not such associations is modified from the calcium so you’re able to magnesium (Ca:Mg) ratio.
Calcium intake did not show a dose–response association with incident adenoma of any size/stage (P-pattern = 0.17), but followed an inverse trend when restricted to synchronous/advanced adenoma cases (P-trend = 0.05). This inverse trend was mainly in participants with Ca:Mg ratios between 1.7 and 2.5 (P-trend = 0.05). No significant associations were observed for metachronous adenoma. Calcium intake was inversely associated with CRC (P-trend = 0.03); the association was primarily present for distal CRC (P-trend = 0.01). (more…)